Modern Neuromodulation: Vagus Nerve Stimulation in Advancing Care for Patients With Drug-Resistant Epilepsy and Treatment-Resistant Depression

QoL Matters: Brain Stem Stimulation in Patients With Unipolar Depression

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  • Overview

    This series of bite-sized episodes contains important information on using vagus nerve stimulation (VNS) for the treatment of drug-resistant epilepsy (DRE) and treatment-resistant depression (TRD). Drs. Raman Sankar and Scott Aaronson discuss best practices for identifying and treating patients as well as programming strategies for VNS.

  • Disclosure of Relevant Financial Relationships

    In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    Faculty:

    Raman Sankar, MD, PhD
    Professor Emeritus
    Neurology and Pediatrics
    David Geffen School of Medicine
    Los Angeles, CA

    Dr. Sankar has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months: 

    Advisor/Consultant: Jazz Pharma, SK, UCB

    Scott Aaronson, MD
    Chief Science Officer
    Institute for Advanced Diagnostics and Therapeutics
    Psychiatrist, The Retreat at Sheppard Pratt
    Baltimore, MD

    Dr. Aaronson has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months: 

    Advisor/Consultant: Genomind, Janssen, LivaNova, Neuronetics, Sage Therapeutics
    Contracted Researcher: Compass Pathways, Neuronetics

    Reviewers/Content Planners/Authors: 

    • Cindy Davidson has no relevant relationships to disclose.
    • Rosanne Strauss, PharmD, has no relevant relationships to disclose.
    • Brian P. McDonough, MD, FAAFP, has no relevant relationships to disclose. 
  • Learning Objectives

    Upon completion of this activity, learners should be better able to:

    • Compare and contrast the mechanisms of action of the following neuromodulation therapies in the management of epilepsy and depression: vagus nerve stimulation (VNS), deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), and electroconvulsive therapy (ECT) 
    • Analyze the combined impact of mood disorders and epilepsy on patients’ quality of life 
    • Evaluate the efficacy and safety profiles of VNS in patients with drug-resistant epilepsy (DRE) and treatment-resistant depression (TRD)  
    • Apply optimal programming strategies for VNS therapy in patients with DRE or TRD 
  • Target Audience

    This activity has been designed to meet the educational needs of neurologists and psychiatrists as well as all other physicians, physician assistants, nurse practitioners, nurses, pharmacists, and healthcare providers involved in managing patients with VNS. 

  • Accreditation and Credit Designation Statements

    In support of improving patient care, Global Learning Collaborative (GLC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

    Global Learning Collaborative (GLC) designates this activity for a maximum of .5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Global Learning Collaborative (GLC) designates this activity for .5 nursing contact hour(s). Nurses should claim only the credit commensurate with the extent of their participation in the activity.

    Global Learning Collaborative (GLC) designates this activity for .5 contact hour(s)/0.05 CEUs of pharmacy contact hour(s).

    The Universal Activity Number for this program is JA0006235-0000-25-073-H01-P. This learning activity is knowledge-based. Your CE credits will be electronically submitted to the NABP upon successful completion of the activity. Pharmacists with questions can contact NABP customer service (custserv@nabp.net). 

    Global Learning Collaborative (GLC) has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit(s) for activities planned in accordance with AAPA CME Criteria. This activity is designated for .5 AAPA Category 1 CME credit(s). Approval is valid until June 30, 2026. PAs should claim only the credit commensurate with the extent of their participation in the activity.

  • Provider(s)/Educational Partner(s)


    Prova Education designs and executes continuing education founded on evidence-based medicine, clinical need, gap analysis, learner feedback, and more. Our mission is to serve as an inventive and relevant resource for clinical content and educational interventions across a broad spectrum of specialties. Prova Education's methodology demonstrates a commitment to continuing medical education and the innovative assessment of its effects. Our goal is clear—to develop and deliver the best education in the most impactful manner and to verify its results with progressive outcomes research.

  • Commercial Support

    This activity is supported by an independent educational grant from LivaNova USA, Inc.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to access a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site. 

    Reproduction Prohibited 

    Reproduction of this material is not permitted without written permission from the copyright owner. 

  • System Requirements

    • Supported Browsers (2 most recent versions):
      • Google Chrome for Windows, Mac OS, iOS, and Android
      • Apple Safari for Mac OS and iOS
      • Mozilla Firefox for Windows, Mac OS, iOS, and Android
      • Microsoft Edge for Windows
    • Recommended Internet Speed: 5Mbps+

  • Publication Dates

    Release Date:

    Expiration Date:

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