In 2019, the REDUCE-IT trial studying eicosapentaenoic acid (EPA), a purified form of omega-3 fatty acid, was published and demonstrated a dramatic 25% reduction in major cardiovascular events. In 2020, the STRENGTH trial that used a carboxylic acid formulation of combined EPA and docosahexaenoic acid (DHA), was surprisingly neutral and the study was halted for futility. A recent post hoc analysis of the STRENGTH study failed to show a difference in the primary endpoint in the highest tertile group receiving the EPA/DHA carboxylic acid treatment. Why did these two major omega-3 clinical trials studying patients with elevated triglyceride levels have disparate results? What does this mean for our patients? Join two experts, Drs. Michael Miller and Brian Olshansky, as they assess the different trials and offer their perspective on the clinical and scientific implications of the results.
In accordance with the ACCME Standards for Commercial Support, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. GLC resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.
Michael Miller, MD, FACC, FAHA
Professor of Cardiovascular Medicine, Epidemiology & Public Health
University of Maryland School of Medicine
Staff Physician, Baltimore VAMC
Director, Center for Preventive Cardiology
University of Maryland Medical Center
Consulting Fees: Amarin, Pfizer
Brian Olshansky, MD, FACCP, FAHA, FHRS, FESC
Emeritus Professor Medicine
University of Iowa College of Medicine
Iowa City, IA
Consulting Fees: Amarin, Lundbeck, Sanofi Aventis
Other: Amarin: Chair, DMC REDUCE-IT; Boehringer Ingelheim: US Co-coordinator for GLORIA-AF
- Ben Caref, PhD, has nothing to disclose.
- Sue Grossman has nothing to disclose.
- Libby Lurwick has nothing to disclose.
- Brian P. McDonough, MD, FAAFP, has nothing to disclose.
After participating in this educational activity, participants should be better able to:
- Describe the spectrum and clinical implications of large-scale outcomes trials of recent omega-3 fatty acids on ASCVD events
- Appreciate the differences between omega-3 fatty acids and their formulations and how they impact ASCVD events
This activity is designed to meet the educational needs of cardiologists, endocrinologists, internists, diabetologists, lipidologists, and others with an interest in managing severe dyslipidemia.
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Global Learning Collaborative designates this enduring material for a maximum of .25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
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This activity is supported by an independent educational grant from Amarin Pharma.
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