High-Risk HFrEF: Who Will Benefit Most from Novel Therapies?

High-Risk HFrEF: Who Will Benefit Most from Novel Therapies?

High-Risk HFrEF: Who Will Benefit Most from Novel Therapies?

Are you using appropriate therapies for your patients with heart failure who are at high risk or have been rehospitalized despite maximal therapy?

Available credits: 0.25

Time to complete: 15 minutes


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  • Overview

    Have you started using newly approved therapies when caring for your patients with heart failure with reduced ejection fraction (HFrEF)? Tune in to hear Drs. Javed Butler and Shelley Zieroth discuss strategies you can use to determine the best treatment approaches for your most challenging patients. A 3D mechanism of action animation is included to help you understand the workings of novel classes of agents in heart failure. Make sure you get with the guidelines, because guideline-directed medical therapy really does work.

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    Javed Butler, MD, MBA, MPH
    Professor & Chair, Department of Medicine
    University of Mississippi Medical Center
    Jackson, MS

    Consulting Fees: Abbott, Adrenomed, Amgen, Array, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, CVRx, G3 Pharmaceuticals, Impulse Dynamics, Innolife, Janssen, LivaNova, Luitpold, Medtronic, Merck, Novartis, Novo Nordisk, Relypsa, Roche, V-Wave Ltd., Vifor Pharma

    Shelley Zieroth, MD
    Director, SBH Heart Failure and Transplant Clinics
    St. Boniface Hospital
    Winnipeg, MB, Canada

    Consulting Fees: Abbott, Akcea, AstraZeneca, Amgen, Alnylam, Boehringer Ingelheim, Eli-Lilly, Merck, Novartis, Pfizer, Servier
    Commercial Interest Speakers Bureau: Abbott, Akcea, AstraZeneca, Amgen, Alnylam, Boehringer Ingelheim, Eli Lilly, Merck, Novartis, Pfizer, Servier
    Contracted Research: Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Eidos, Merck, Novartis, Servier

    Reviewers/Content Planners/Authors:

    • Sean T. Barrett has nothing to disclose.
    • Megan Clem has nothing to disclose.
    • Cindy Davidson has nothing to disclose.
    • Amanda Hilferty has nothing to disclose.
    • Brian P. McDonough, MD, FAAFP, has nothing to disclose.
    • Mario Trucillo, PhD, MS, has nothing to disclose.
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    • Assess the most recent efficacy and safety data for novel agents for the management of HFrEF
    • Evaluate the potential clinical impact of novel therapies in treating worsening HFrEF in high-risk patients and reducing residual risk in patients on guideline-directed medical therapy (GDMT)
    • Select appropriate HF treatment strategies based on the most recent guidelines to mitigate residual risk and reduce morbidity and mortality
  • Target Audience

    This activity is designed to meet the educational needs of cardiologists and primary care physicians who treat heart failure.

  • Accreditation and Credit Designation Statements

    In support of improving patient care, Global Learning Collaborative (GLC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

    Global Learning Collaborative (GLC) designates this enduring activity for a maximum of .25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Global Learning Collaborative (GLC) designates this activity for .25 nursing contact hours. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

  • Provider(s)/Educational Partner(s)

    Our ultimate goal is to improve the care being delivered to patients, and our high quality, evidence-based CME initiatives reflect our dedication to the creation and execution of excellence and are the product of shared research, knowledge, and clinical practice skills across the healthcare continuum.

  • Commercial Support

    This activity is supported by an independent educational grant from Bayer AG.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Medtelligence. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Medtelligence you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited
    Reproduction of this material is not permitted without written permission from the copyright owner.

  • System Requirements

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