Natriuretic peptides (NP) are hormones released from the heart that reduce blood pressure, insulin resistance and body fat accumulation. Low NP levels may be associated with increased risk for type 2 diabetes, a condition more common in African-Americans and Hispanics than in white individuals.
In a recent PLOS ONE publication, Deepak Gupta, MD, MSCI, and colleagues examined serum NP levels from 3,220 multiethnic participants in the Diabetes Prevention Program, a randomized trial that investigated approaches to type 2 diabetes prevention.
They reported lower NP levels in African-Americans and Hispanics compared with white individuals. Over a two-year follow-up, NP levels remained lower in African-Americans compared with white individuals regardless of trial intervention.
These findings suggest variation in NP levels may contribute to racial/ethnic differences in susceptibility to diabetes mellitus and other cardio-metabolic conditions. Future studies should examine whether pharmacologically augmenting the NP system reduces the risk of diabetes, particularly in high-risk groups such as African-American and Hispanic individuals.