New, Minimally Invasive Biomarker-Based Strategy 90% Successful in Detecting Esophageal Cancer

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In a small but rigorous pilot study, Johns Hopkins Medicine researchers have shown that a novel, minimally invasive biomarker-based strategy they developed was 90% successful in detecting esophageal squamous cell carcinoma (ESCC), the predominant subtype of esophageal cancer worldwide.

Although less common than some other tumor types in the United States, esophageal cancer remains the sixth-most common cause of cancer death worldwide, claiming the lives of more than half a million people annually, especially in low- to moderate-income countries in Africa, Asia and other continents. Early detection of this deadly disease greatly improves survival, but by the time symptoms -; such as trouble swallowing, weight loss, anemia or bleeding -; become apparent, it's often too late to cure.

The new case-control study combining a swallowable, retrievable device with molecular biomarkers is described in an April 26 Research Letter published in the high-impact journal, Gastroenterology.

In the article, gastroenterologist Stephen Meltzer, M.D., the Myerberg-Hendrix and American Cancer Society Professor of Medicine and Oncology at the Johns Hopkins University School of Medicine, said the strategy combines sensitive, specific DNA-based biomarkers with a device consisting of a small gelatin capsule housing a soft sponge attached to a flexible string that can be swallowed. After a few minutes, the capsule dissolves in the stomach, releasing a sponge that's 2 centimeters in diameter -; about the size of a nickel. As the person administering the capsule pulls the sponge out by the string, it travels upward, collecting cells that line the surface of the patient's esophagus.

"With esophageal cancer, diagnosis is a matter of life and death," says Meltzer, who has dedicated decades of his career to the detection and prevention of this disease. "Currently, there is no inexpensive, minimally invasive screening tool that can be used regularly to diagnose those at risk, including people above age 45 with chronic severe acid reflux disease and those who smoke tobacco, inhale wood smoke (as in some low-income countries), use alcohol or are obese."

In the newly reported case-control study, Meltzer's research team administered the test to 94 people -; including many in Uganda (a nation with a high-risk population) as well as patients at The Johns Hopkins Hospital. A standard value metric commonly used to indicate accuracy in biomarker research is something called Area Under the Curve (AUC). In this study, the three-biomarker gene algorithm used to detect ESCC (cg20655070, SLC35F1, ZNF132), including age as a fourth parameter, yielded an AUC of 0.94, which is generally considered very strong in biomarker research studies. In a totally independent, subsequently collected test set of patients collected after the biomarker model was constructed, the algorithm successfully classified 90% of patients, with a specificity of 0.87 and a sensitivity (what proportion of people with the disease the test detects) of 0.92. After the test procedure, there was no evidence of bleeding, pain, trauma or other severe adverse reactions among participants.

ESCC comprises 80% of esophageal cancers globally, with particularly high rates in Asia and southeastern Africa. Currently, people suspected of having esophageal cancer undergo endoscopies and biopsies, which are very expensive, risky and often unavailable in developing countries, where the risk for the disease is highest.

In the U.S., esophageal cancers overall number about 18,000 per year. Notably, the five-year survival rate is less than 20%, according to the American Cancer Society.

Meltzer says these preliminary results suggest that larger screening trials should be conducted in high-risk populations around the world.

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